Overlapping Risky Decision-Making and Olfactory Processing Ability in HIV-Infected Individuals.

ABSTRACT:

Objective

Given neuroimaging evidences of overlap in the circuitries for decision-making and olfactory processing, we examined the hypothesis that impairment in psychophysical tasks of olfaction would independently predict poor performances on Iowa Gambling Task (IGT), a laboratory task that closely mimics real-life decision-making, in a US cohort of HIV-infected (HIV+) individuals.

Method

IGT and psychophysical tasks of olfaction were administered to a Washington DC-based cohort of largely African American HIV+ subjects (N=100), and to a small number of demographically-matched non-HIV healthy controls (N=43) from a different study. Constructs of olfactory ability and decision-making were examined through confirmatory factor analysis (CFA). Structural equation models (SEMs)

SUBMITTER: Jackson C 

PROVIDER: S-EPMC5648356 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature