Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors.

ABSTRACT: The human distal limbs have a high spatial acuity for noxious stimuli but a low density of pain-sensing neurites. To elucidate mechanisms underlying regional differences in processing nociception, we sparsely traced non-peptidergic nociceptors across the body using a newly generated Mrgprd^CreERT2 mouse line. We found that mouse plantar paw skin is also innervated by a low density of Mrgprd⁺ nociceptors, while individual arbors in different locations are comparable in size. Surprisingly, the central arbors of plantar paw and trunk innervating nociceptors have distinct morphologies in the spinal cord. This regional difference is well correlated with a heightened signal transmission for plantar paw circuits, as revealed by both spinal cord slice recordings and beh

SUBMITTER: Olson W 

PROVIDER: S-EPMC5648527 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature