Metabolic control by sirtuins and other enzymes that sense NAD⁺, NADH, or their ratio.

ABSTRACT: NAD⁺ is a dinucleotide cofactor with the potential to accept electrons in a variety of cellular reduction-oxidation (redox) reactions. In its reduced form, NADH is a ubiquitous cellular electron donor. NAD⁺, NADH, and the NAD⁺/NADH ratio have long been known to control the activity of several oxidoreductase enzymes. More recently, enzymes outside those participating directly in redox control have been identified that sense these dinucleotides, including the sirtuin family of NAD⁺-dependent protein deacylases. In this review, we highlight examples of non-redox enzymes that are controlled by NAD⁺, NADH, or NAD⁺/NADH. In particular, we focus on the sirtuin family and assess the current evidence that the sirtuin enzymes sense th

SUBMITTER: Anderson KA 

PROVIDER: S-EPMC5648639 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature