Dopamine-mediated photothermal theranostics combined with up-conversion platform under near infrared light.

ABSTRACT: An organic-inorganic hybrid core-shell nanostructure, based on mesoporous silica coated upconversion core-shell nanoparticles (NaGdF₄:Yb,Er@NaGdF₄:Yb@mSiO₂-Dopa abbreviated here as UCNP@mSiO₂-Dopa) that stably incorporates dopamine (Dopa) in the silica layer was introduced as a theranostic nanoplatform for optical imaging guided photothermal therapy (PTT) using NIR excitation. Silica-attaching polyethylenimine make the Dopa transforms into an active form (transferred Dopa) that strongly absorbs light under single 980 nm irradiation. We show that the activated UCNP@mSiO₂-Dopa nanoplatform is able to produce a pronounced photothermal effect, that elevates water temperature from room temperature to 41.8 °C within 2 minutes, while concurre

SUBMITTER: Lv R 

PROVIDER: S-EPMC5648774 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature