MAGT1-mediated disturbance of Mg²⁺ homeostasis lead to exhausted of HBV-infected NK and CD8⁺ T cells.

ABSTRACT: The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium ([Mg²⁺]i) levels. It has been shown that MAGT1 was involved in the disorder in Mg²⁺ homeostasis after Epstein-Barr virus (EBV) infection. Here, we identified the effects of MAGT1-mediated disturbance of Mg²⁺ homeostasis on chronic hepatitis B virus (HBV)-infected natural killer (NK) and CD8⁺ T cells. The expression of MAGT1 was gradually decreased with the increase of infected time in CD8⁺ T cells, but not with that in NK cells, of the patients. Decreased level of intracellular free Mg²⁺ ([Mg²⁺]i) leads to defective expression of programmed cell death 1 (PD-1) and the NK activating receptor (NKG2D) in NK and CD8⁺

SUBMITTER: Diao B 

PROVIDER: S-EPMC5648775 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature