Coordinated Regulation of the EII^Man and fruRKI Operons of Streptococcus mutans by Global and Fructose-Specific Pathways.

ABSTRACT: The glucose/mannose-phosphotransferase system (PTS) permease EII^Man encoded by manLMN in the dental caries pathogen Streptococcus mutans has a dominant influence on sugar-specific, CcpA-independent catabolite repression (CR). Mutations in manL affect energy metabolism and virulence-associated traits, including biofilm formation, acid tolerance, and competence. Using promoter::reporter fusions, expression of the manLMN and the fruRKI operons, encoding a transcriptional regulator, a fructose-1-phosphate kinase and a fructose-PTS permease EII^Fru, respectively, was monitored in response to carbohydrate source and in mutants lacking CcpA, FruR, and components of EII^Man Expression of genes for EII^Man and EII^Fru</

SUBMITTER: Zeng L 

PROVIDER: S-EPMC5648919 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature