Estimating prognosis in patients with acute myocardial infarction using personalized computational heart models.

ABSTRACT: Biomechanical computational models have potential prognostic utility in patients after an acute ST-segment-elevation myocardial infarction (STEMI). In a proof-of-concept study, we defined two groups (1) an acute STEMI group (n = 6, 83% male, age 54 ± 12 years) complicated by left ventricular (LV) systolic dysfunction; (2) an age- and sex- matched hyper-control group (n = 6, 83% male, age 46 ± 14 years), no prior history of cardiovascular disease and normal systolic blood pressure (SBP < 130 mmHg). Cardiac MRI was performed in the patients (2 days & 6 months post-STEMI) and the volunteers, and biomechanical heart models were synthesized for each subject. The candidate parameters included normalized active tension (AT ^norm) and active tension at the resting sarcomere length (T

SUBMITTER: Gao H 

PROVIDER: S-EPMC5648923 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature