Listeria monocytogenes and Shigella flexneri Activate the NLRP1B Inflammasome.

ABSTRACT: Activation of the innate immune receptor NLRP1B leads to the formation of an inflammasome, which induces autoproteolytic processing of pro-caspase-1, and ultimately to the release of inflammatory cytokines and to the execution of pyroptosis. One of the signals to which NLRP1B responds is metabolic stress that occurs in cells deprived of glucose or treated with metabolic inhibitors. NLRP1B might therefore sense microbial infection, as intracellular pathogens such as Listeria monocytogenes and Shigella flexneri cause metabolic stress as a result of nutrient scavenging and host cell damage. Here we addressed whether these pathogens activate the NLRP1B inflammasome. We found that Listeria infection activated the NLRP1B inflammasome in a reconstituted fibroblast model. Acti

SUBMITTER: Neiman-Zenevich J 

PROVIDER: S-EPMC5649023 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature