Ontology highlight
ABSTRACT:
SUBMITTER: Agrawal P
PROVIDER: S-EPMC5649440 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Cancer cell 20170601 6
Association of aberrant glycosylation with melanoma progression is based mainly on analyses of cell lines. Here we present a systems-based study of glycomic changes and corresponding enzymes associated with melanoma metastasis in patient samples. Upregulation of core fucosylation (FUT8) and downregulation of α-1,2 fucosylation (FUT1, FUT2) were identified as features of metastatic melanoma. Using both in vitro and in vivo studies, we demonstrate FUT8 is a driver of melanoma metastasis which, whe ...[more]