C/EBPβ is required for survival of Ly6C^- monocytes.

ABSTRACT: The transcription factor CCAAT/enhancer-binding protein β (C/EBPβ) is highly expressed in monocytes/macrophages. However, its roles in monopoiesis are largely unknown. Here, we investigated the roles of C/EBPβ in monopoiesis. Further subdivision of monocytes revealed that Cebpb messenger RNA was highly upregulated in Ly6C^- monocytes in bone marrow. Accordingly, the number of Ly6C^- monocytes was significantly reduced in Cebpb^-/- mice. Bone marrow chimera experiments and Mx1-Cre-mediated deletion of Cebpb revealed a cell-intrinsic and monocyte-specific requirement for C/EBPβ in monopoiesis. In Cebpb^-/- mice, turnover of Ly6C^- monocytes was highly accelerated and apoptosis of Ly6C^- monocytes w

SUBMITTER: Tamura A 

PROVIDER: S-EPMC5649551 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature