No association between dietary sodium intake and the risk of multiple sclerosis.

ABSTRACT:

Objective

To prospectively investigate the association between dietary sodium intake and multiple sclerosis (MS) risk.

Methods

In this cohort study, we assessed dietary sodium intake by a validated food frequency questionnaire administered every 4 years to 80,920 nurses in the Nurses' Health Study (NHS) (1984-2002) and to 94,511 in the Nurses' Health Study II (NHSII) (1991-2007), and calibrated it using data from a validation study. There were 479 new MS cases during follow-up. We used Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the effect of energy-adjusted dietary sodium on MS risk, adjusting also for age, latitude of residence at age 15, ancestry, body mass index at age 18, supplemental vitamin D intake, cigarette s

SUBMITTER: Cortese M 

PROVIDER: S-EPMC5649760 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature