¹H-MRS metabolites and rate of β-amyloid accumulation on serial PET in clinically normal adults.

ABSTRACT:

Objective

To assess whether noninvasive proton magnetic resonance spectroscopy (¹H-MRS) tissue metabolite measurements at baseline can predict an increase in the rate of β-amyloid (Aβ) accumulation on serial PET in clinically normal (CN) older adults.

Methods

Consecutive participants aged 60 years and older (n = 594) from the Mayo Clinic Study of Aging who were CN at baseline and who underwent ¹H-MRS from the posterior cingulate voxel and longitudinal ¹¹C-Pittsburgh compound B (PiB)-PET were included. The rate of Aβ accumulation by serial cortical PiB standardized uptake value ratios was estimated as a function of baseline ¹H-MRS metabolite ratios and time using mixed-effect models adjusted for age, sex, and APOE ε4. Effect

SUBMITTER: Nedelska Z 

PROVIDER: S-EPMC5649764 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature