Effects of Omalizumab on Rhinovirus Infections, Illnesses, and Exacerbations of Asthma.

ABSTRACT:

Rationale

Allergic inflammation has been linked to increased susceptibility to viral illnesses, but it is unclear whether this association is causal.

Objectives

To test whether omalizumab treatment to reduce IgE would shorten the frequency and duration of rhinovirus (RV) illnesses in children with allergic asthma.

Methods

In the PROSE (Preventative Omalizumab or Step-up Therapy for Severe Fall Exacerbations) study, we examined children with allergic asthma (aged 6-17 yr; n = 478) from low-income census tracts in eight U.S. cities, and we analyzed virology for the groups randomized to treatment with guidelines-based asthma care (n = 89) or add-on omalizumab (n = 259). Weekly nasal mucus samples were analyzed for RVs, and respiratory symptoms and asthma exacerbations we

SUBMITTER: Esquivel A 

PROVIDER: S-EPMC5649984 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature