Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers.

ABSTRACT: Chronic obstructive pulmonary disease is the third leading cause of death worldwide. Gene expression profiling across multiple regions of the same lung identified genes significantly related to emphysema. We sought to determine whether the lung and epithelial expression of 127 emphysema-related genes was also related to lung function in independent cohorts, and whether any of these genes could be used as biomarkers in the peripheral blood of patients with chronic obstructive pulmonary disease. To that end, we examined whether the expression levels of these genes were under genetic control in lung tissue (n = 1,111). We then determined whether the mRNA levels of these genes in lung tissue (n = 727), small airway epithelial cells (n = 238), and peripheral blood (n = 620) were significantly r

SUBMITTER: Obeidat M 

PROVIDER: S-EPMC5650084 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature