Atopic asthmatic immune phenotypes associated with airway microbiota and airway obstruction.

ABSTRACT:

Background

Differences in asthma severity may be related to inflammation in the airways. The lower airway microbiota has been associated with clinical features such as airway obstruction, symptom control, and response to corticosteroids.

Objective

To assess the relationship between local airway inflammation, severity of disease, and the lower airway microbiota in atopic asthmatics.

Methods

A cohort of young adult, atopic asthmatics with intermittent or mild/moderate persistent symptoms (n = 13) were assessed via bronchoscopy, lavage, and spirometry. These individuals were compared to age matched non-asthmatic controls (n = 6) and to themselves after six weeks of treatment with fluticasone propionate (FP). Inflammation of the airways was assessed via a cytokine and che

SUBMITTER: Turturice BA 

PROVIDER: S-EPMC5650135 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature