Impaired glucose metabolism in subjects with the Williams-Beuren syndrome: A five-year follow-up cohort study.

ABSTRACT:

Objective

The Williams-Beuren syndrome (WS) is associated with impaired glucose metabolism (IGM) early in adulthood. However, the pathophysiology of IGM remains poorly defined, due to the lack of longitudinal studies investigating the contribution of β-cell dysfunction and impaired insulin sensitivity. This study aimed at assessing incidence of IGM and the underlying mechanisms in WS adults.

Methods

This observational, longitudinal (5-year), cohort study enrolled thirty-one consecutive WS subjects attending a tertiary referral center. An oral glucose tolerance test (OGTT) was performed yearly and used to classify patients as normal or IGM, including impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) and diabetes mellitus (DM), and to calculate surrogate m

SUBMITTER: Lunati ME 

PROVIDER: S-EPMC5650138 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature