Histopathological features of endometrial carcinomas associated with POLE mutations: implications for decisions about adjuvant therapy.

ABSTRACT:

Aims

To characterize the histomorphological features of endometrial carcinomas (ECs) harbouring polymerase ε (POLE) mutations.

Methods and results

Forty-three ECs with POLE mutations were compared with a cohort of 202 ECs. Most POLE-mutated ECs were endometrioid [34/43 (79%)]; the remaining tumours were mixed [6/43 (14%)], serous [2/43 (5%)], and clear cell [1/43 (2%)]. The endometrioid carcinomas were predominantly International Federation of Gynecology and Obstetrics grade 3 (27/43, 63%). The histotype distribution did not differ from that of control ECs (P = 0.69), but the grade of the EC was higher (P < 0.0005). Both nuclear grade and mitotic index were significantly higher in POLE-mutated ECs than in the comparison cohort. POLE-mutated ECs were associated with peritumor

SUBMITTER: Bakhsh S 

PROVIDER: S-EPMC5650229 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature