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H. pylori attenuates TNBS-induced colitis via increasing mucosal Th2 cells in mice.


ABSTRACT: There is an epidemiological inverse relationship between Helicobacter pylori (H. pylori) infection and Crohn's disease (CD). However, whether H. pylori plays a protective role against CD remains unclear. Since 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis is thought to resemble CD, we investigated whether H. pylori can attenuate TNBS-induced colitis in mice. Here we show that H. pylori can attenuate the severity of TNBS-induced colitis. In addition, H. pylori not only down-regulates Th17 and Th1 cytokine expression, but can up-regulate Th2 cytokine expression and increase the Th2:Th17 ratio of CD4+ T in the colonic mucosa of TNBS-induced colitis. Our results indicate that H. pylori attenuates TNBS-induced colitis mainly through increasing Th2 cells in murine colonic mucosa. Our finding offers a novel view on the role of H. pylori in regulating gastrointestinal immunity, and may open a new avenue for development of therapeutic strategies in CD by making use of asymptomatic H. pylori colonization.

SUBMITTER: Wu YZ 

PROVIDER: S-EPMC5650302 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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<i>H. pylori</i> attenuates TNBS-induced colitis via increasing mucosal Th2 cells in mice.

Wu Yi-Zhong YZ   Tan Gao G   Wu Fang F   Zhi Fa-Chao FC  

Oncotarget 20170518 43


There is an epidemiological inverse relationship between <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and Crohn's disease (CD). However, whether <i>H. pylori</i> plays a protective role against CD remains unclear. Since 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis is thought to resemble CD, we investigated whether <i>H. pylori</i> can attenuate TNBS-induced colitis in mice. Here we show that <i>H. pylori</i> can attenuate the severity of TNBS-induced colitis. In additi  ...[more]

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