Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages.

ABSTRACT: Dietary restriction has been recognized as a healthy and natural therapy for cancer. It is reported that different forms of dietary restriction can promote anti-tumor immunity. However, it is not clear how fasting affects tumor-associated macrophages (TAMs). This study aims to investigate the relationship between fasting and antitumor immunity in terms of tumor-associated macrophages. In vivo, the results showed that alternate day fasting for 2 weeks inhibitted the tumor growth of mice without causing a reduction of body weight. Meanwhile, M2 polarization of tumor-associated macrophages in tumor tissues of alternate day fasting group was also decreased. In vitro, fasting induced the autophagy of CT26 cells, decreased the generation of extracellular adenosine by supressing the

SUBMITTER: Sun P 

PROVIDER: S-EPMC5650369 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature