Dietary menthol-induced TRPM8 activation enhances WAT "browning" and ameliorates diet-induced obesity.

ABSTRACT: Beige adipocytes are a new type of recruitable brownish adipocytes, with highly mitochondrial membrane uncoupling protein 1 expression and thermogenesis. Beige adipocytes were found among white adipocytes, especially in subcutaneous white adipose tissue (sWAT). Therefore, beige adipocytes may be involved in the regulation of energy metabolism and fat deposition. Transient receptor potential melastatin 8 (TRPM8), a Ca²⁺-permeable non-selective cation channel, plays vital roles in the regulation of various cellular functions. It has been reported that TRPM8 activation enhanced the thermogenic function of brown adiposytes. However, the involvement of TRPM8 in the thermogenic function of WAT remains unexplored. Our data revealed that TRPM8 was expressed in mouse white adipocytes at

SUBMITTER: Jiang C 

PROVIDER: S-EPMC5650405 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature