Correlation between KLOTHO gene and mild cognitive impairment in the Uygur and Han populations of Xinjiang.

ABSTRACT: The secretive Klotho protein is an anti-aging regulatory hormone that plays a physiological role in many target organs. The present study aims to investigate the correlation between Klotho gene and mild cognitive impairment (MCI) in Uygur and Han populations in Xinjiang. From July 2008 to April 2014, stratified random multistage cluster sampling was used in combination with the methods of on-site questionnaire and household survey to conduct a cross-sectional MCI investigation on selected Uygur and Han subjects aged over 60 years old in Xinjiang region. 323 Uygur and Han MCI patients were randomly selected and matched with 343 subjects in the normal control group. SNaPshot technique was used to detect the polymorphisms of Klotho gene. A case-control associated analysis was co

SUBMITTER: Abulizi P 

PROVIDER: S-EPMC5650410 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature