Statin use and non-melanoma skin cancer risk: a meta-analysis of randomized controlled trials and observational studies.

ABSTRACT:

Background

Existing evidence of the association between statin use and non-melanoma skin cancer (NMSC) risk has been inconsistent.

Objective

To maximize statistical power to synthesize prospective evidence on this relationship.

Materials and methods

PubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrial.gov were systematically searched up to December 11, 2016. A random-effects meta-analysis was conducted to calculate summary estimates.

Results

Our meta-analysis of 14 randomized controlled trials (RCTs) including 63,157 subjects showed no significant association between statin use and NMSC risk (RR = 1.09, 95%CI = 0.85-1.39). However, meta-analysis of four observational studies including 1,528,215 participants showed si

SUBMITTER: Yang K 

PROVIDER: S-EPMC5650431 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature