Clinical study of ^99mTc-3P-RGD2 peptide imaging in osteolytic bone metastasis.

ABSTRACT:

Objective

To investigate the value of integrin α_vβ₃ targeted imaging with ^99mTc-HYNIC-PEG₄-E[PEG₄-c(RGDfk)]₂ (^99mTc-3P-RGD₂) as a radiotracer in dectecting osteolytic bone metastases.

Methods

This is a retrospective study involving a cohort of 69 consecutive patients including 59 with lung cancer and 10 with other cancers. Patients were required to receive whole body scan (WBS) and regional SPECT/CT imaging with ^99mTc-3P-RGD₂ (RGD imaging) and ^99mTc-MDP (MDP imaging) as a radiotracer successively within days. Final diagnosis was based on comprehensive assessment of all available data including case history, CT, MRI, SPECT/CT, PET/CT, histopathology and 6-1

SUBMITTER: Shao G 

PROVIDER: S-EPMC5650448 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature