Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma.

ABSTRACT: Resistance to targeted therapy is an ongoing problem for the successful treatment of Stage IV metastatic melanoma. For many patients, the use of targeted therapies, such as BRAF kinase inhibitors, were initially promising yet resistance inevitably occurred. Even after combining BRAF kinase inhibitors with MEK pathway inhibitors to offset re-activation of the MAP kinase pathway, resistance is still documented. Similarly, outcomes with immune checkpoint inhibitors as monotherapy were optimistic for some patients without relapse or progression, yet the majority of patients undergoing monotherapy have progressive disease. Will immunotherapy and combination therapy trials overcome resistance in metastatic melanoma? In an effort to treat resistant disease, new clinical trials evaluating the comb

SUBMITTER: Keller HR 

PROVIDER: S-EPMC5650456 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature