Production of highly stable spray dried phage formulations for treatment of Pseudomonas aeruginosa lung infection.

ABSTRACT: The potential of bacteriophage therapy for the treatment of pulmonary infections caused by antibiotic-resistant bacteria has been well recognised. The purpose of this study was to investigate the effect of excipients on stabilisation and aerosolisation of spray dried powders of morphologically different phages - PEV podovirus and PEV myovirus. Seven anti-pseudomonal phages were screened against 90 clinical strains of bacterial hosts and three of the phages were selected for formulation study based on the host range. Design of experiments was utilised to assess the effect of different excipients on the stabilisation and aerosolisation of spray dried phages. Both podovirus and myovirus phages were stable in spray dried formulations containing trehalose or lactose and leucine as excipients wi

SUBMITTER: Chang RY 

PROVIDER: S-EPMC5650506 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature