Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder.

ABSTRACT:

Background

The first global lipidomic profiles associated with urothelial cancer of the bladder (UCB) and its clinical stages associated with progression were identified.

Objective

To identify lipidomic signatures associated with survival and different clinical stages of UCB.

Design, setting, and participants

Pathologically confirmed 165 bladder-derived tissues (126 UCB, 39 benign adjacent or normal bladder tissues). UCB tissues included Ta (n=16), T1 (n=30), T2 (n=43), T3 (n=27), and T4 (n=9); lymphovascular invasion (LVI) positive (n=52) and negative (n=69); and lymph node status N0 (n=28), N1 (n=11), N2 (n=9), N3 (n=3), and Nx (n=75).

Results and limitations

UCB tissues have higher levels of phospholipids and fatty acids, and reduced levels of triglycerides

SUBMITTER: Piyarathna DWB 

PROVIDER: S-EPMC5650548 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature