Integration of Recurrent Somatic Mutations with Clinical Outcomes: A Pooled Analysis of 1049 Patients with Clear Cell Renal Cell Carcinoma.

ABSTRACT:

Background

Analyses of associations between clinicopathologic outcomes and recurrent somatic mutations in clear cell renal cell carcinoma (ccRCC) have been limited to individual cohorts.

Objective

To define clinicopathologic associations between specific mutations and ccRCC disease characteristics.

Design, setting, and participants

DNA sequencing data were pooled from three collaborative genomic cohorts (n=754) and our institutional database (n=295). All patients had clinical data and identification of somatic mutations from their primary tumors.

Outcome measurements and statistical analysis

Analysis of gene mutations for associations with maximal tumor size (linear regression) and pathologic stage (logistic regression). Cancer-specific survival (CSS) and recur

SUBMITTER: Manley BJ 

PROVIDER: S-EPMC5650556 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature