Network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp.

ABSTRACT:

Background

Writer's cramp is a task-specific dystonia impairing writing and sometimes other fine motor tasks. Neuroimaging studies using manifold designs have shown varying results regarding the nature of changes in the disease.

Objective

To clarify and extend the knowledge of underlying changes by investigating functional connectivity (FC) in intrinsic connectivity networks with putative sensorimotor function at rest in an increased number of study subjects.

Methods

Resting-state functional magnetic resonance imaging with independent component analysis was performed in 26/27 writer's cramp patients/healthy controls, and FC within and between resting state networks with putative sensorimotor function was compared. Additionally, voxel-based morphometry was carried out

SUBMITTER: Mantel T 

PROVIDER: S-EPMC5650679 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature