Psychophysiological Interactions in a Visual Checkerboard Task: Reproducibility, Reliability, and the Effects of Deconvolution.

ABSTRACT: Psychophysiological interaction (PPI) is a regression based method to study task modulated brain connectivity. Despite its popularity in functional MRI (fMRI) studies, its reliability and reproducibility have not been evaluated. We investigated reproducibility and reliability of PPI effects during a simple visual task, and examined the effect of deconvolution on the PPI results. A large open-access dataset was analyzed (n = 138), where a visual task was scanned twice with repetition times (TRs) of 645 and 1,400 ms, respectively. We first replicated our previous results by using the left and right middle occipital gyrus as seeds. Then regions of interest (ROI)-wise analysis was performed among 20 visual-related thalamic and cortical regions, and negative PPI effects were found between many

SUBMITTER: Di X 

PROVIDER: S-EPMC5651039 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature