An Alignment-Independent 3D-QSAR Study of FGFR2 Tyrosine Kinase Inhibitors.

ABSTRACT: Purpose: Receptor tyrosine kinase (RTK) inhibitors are widely used pharmaceuticals in cancer therapy. Fibroblast growth factor receptors (FGFRs) are members of RTK superfamily which are highly expressed on the surface of carcinoma associate fibroblasts (CAFs). The involvement of FGFRs in different types of cancer makes them promising target in cancer therapy and hence, the identification of novel FGFR inhibitors is of great interest. In the current study we aimed to develop an alignment independent three dimensional quantitative structure-activity relationship (3D-QSAR) model for a set of 26 FGFR2 kinase inhibitors allowing the prediction of activity and identification of important structural features for these inhibitors. Methods: Pentacle software was used to

SUBMITTER: Jafari B 

PROVIDER: S-EPMC5651062 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature