Predictive Role of F₂-Isoprostanes as Biomarkers for Brain Damage after Neonatal Surgery.

ABSTRACT:

Objective

Neonates have a high risk of oxidative stress during anesthetic procedures. The predictive role of oxidative stress biomarkers on the occurrence of brain injury in the perioperative period has not been reported before.

Methods

A prospective cohort study of patients requiring major surgery in the neonatal period was conducted. Biomarker levels of nonprotein-bound iron (NPBI) in plasma and F₂-isoprostane in plasma and urine before and after surgical intervention were determined. Brain injury was assessed using postoperative MRI.

Results

In total, 61 neonates were included, median gestational age at 39 weeks (range 31-42) and weight at 3000 grams (1400-4400). Mild to moderate brain lesions were found in 66%. Logistic regression analysis showed a sign

SUBMITTER: Stolwijk LJ 

PROVIDER: S-EPMC5651108 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature