Sustained anterior cingulate cortex activation during reward processing predicts response to psychotherapy in major depressive disorder.

ABSTRACT:

Background

The purpose of the present investigation was to evaluate whether pre-treatment neural activation in response to rewards is a predictor of clinical response to Behavioral Activation Therapy for Depression (BATD), an empirically validated psychotherapy that decreases depressive symptoms by increasing engagement with rewarding stimuli and reducing avoidance behaviors.

Methods

Participants were 33 outpatients with major depressive disorder (MDD) and 20 matched controls. We examined group differences in activation, and the capacity to sustain activation, across task runs using functional magnetic resonance imaging (fMRI) and the monetary incentive delay (MID) task. Hierarchical linear modeling was used to investigate whether pre-treatment neural responses predicted cha

SUBMITTER: Carl H 

PROVIDER: S-EPMC5651145 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature