The Transcriptional Network Structure of a Myeloid Cell: A Computational Approach.

ABSTRACT: Understanding the general principles underlying genetic regulation in eukaryotes is an incomplete and challenging endeavor. The lack of experimental information regarding the regulation of the whole set of transcription factors and their targets in different cell types is one of the main reasons to this incompleteness. So far, there is a small set of curated known interactions between transcription factors and their downstream genes. Here, we built a transcription factor network for human monocytic THP-1 myeloid cells based on the experimentally curated FANTOM4 database where nodes are genes and the experimental interactions correspond to links. We present the topological parameters which define the network as well as some global structural features and introduce a relative inuence

SUBMITTER: Espinal-Enriquez J 

PROVIDER: S-EPMC5651161 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature