Blood pressure parameters are associated with all-cause and cause-specific mortality in chronic kidney disease.

ABSTRACT: Previous observational studies reported J or U-shaped associations between blood pressure parameters and mortality in patients with chronic kidney disease (CKD). Here we examined the associations of different blood pressure levels with various causes of death in a CKD population that included patients with eGFR 15-59 ml/min/1.73 m² with underlying hypertension receiving at least one antihypertensive agent. We obtained data on date and cause of death from State Department of Health mortality files and classified deaths into three categories: cardiovascular, malignancy-related, and non-cardiovascular/non-malignancy related. Cox models were fitted for overall mortality, and separate competing risk regression models for each major cause of death category, to evaluate their associati

SUBMITTER: Navaneethan SD 

PROVIDER: S-EPMC5651196 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature