Comparison of effect sizes between enriched and nonenriched trials of analgesics for chronic musculoskeletal pain: a systematic review.

ABSTRACT:

Aims

To investigate the use of an enriched study design on the estimates of treatment effect in analgesic trials for chronic musculoskeletal pain.

Methods

Database searches were conducted from 2004 to 2014. We included randomized placebo-controlled trials evaluating pain medications for chronic musculoskeletal pain. Methodological quality was assessed using the PEDro scale. The estimates of treatment effect on pain and adverse events were compared between enriched and nonenriched designs. Metaregression was used to assess the association between the effect size estimate and the study design controlling for analgesic dose and methodological quality.

Results

We included 108 trials, of which 99 were included in the meta-analysis (n = 44 171). There were no overall differ

SUBMITTER: Yamato TP 

PROVIDER: S-EPMC5651314 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature