Relationship altered between functional T1ρ and BOLD signals in bipolar disorder.

ABSTRACT:

Introduction

Functional neuroimaging typically relies on the blood-oxygen-level-dependent (BOLD) contrast, which is sensitive to the influx of oxygenated blood following neuronal activity. A new method, functional T1 relaxation in the rotating frame (fT1ρ) is thought to reflect changes in local brain metabolism, likely pH, and may more directly measure neuronal activity. These two methods were applied to study activation of the visual cortex in participants with bipolar disorder as compared to controls.

Methods

Thirty-nine participants with bipolar disorder and 32 healthy controls underwent functional neuroimaging during a flashing checkerboard paradigm. Functional images were acquired in alternating blocks of BOLD and fT1ρ. Linear mixed-effect models were used to examine th

SUBMITTER: Shaffer JJ 

PROVIDER: S-EPMC5651386 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature