Predicting mild cognitive impairment from spontaneous spoken utterances.

ABSTRACT: INTRODUCTION:Trials in Alzheimer's disease are increasingly focusing on prevention in asymptomatic individuals. We hypothesized that indicators of mild cognitive impairment (MCI) may be present in the content of spoken language in older adults and be useful in distinguishing those with MCI from those who are cognitively intact. To test this hypothesis, we performed linguistic analyses of spoken words in participants with MCI and those with intact cognition participating in a clinical trial. METHODS:Data came from a randomized controlled behavioral clinical trial to examine the effect of unstructured conversation on cognitive function among older adults with either normal cognition or MCI (ClinicalTrials.gov: NCT01571427). Unstructured conversations (but with standardized preselected topics

SUBMITTER: Asgari M 

PROVIDER: S-EPMC5651423 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature