LCS-TA to identify similar fragments in RNA 3D structures.

ABSTRACT:

Background

In modern structural bioinformatics, comparison of molecular structures aimed to identify and assess similarities and differences between them is one of the most commonly performed procedures. It gives the basis for evaluation of in silico predicted models. It constitutes the preliminary step in searching for structural motifs. In particular, it supports tracing the molecular evolution. Faced with an ever-increasing amount of available structural data, researchers need a range of methods enabling comparative analysis of the structures from either global or local perspective.

Results

Herein, we present a new, superposition-independent method which processes pairs of RNA 3D structures to identify their local similarities. The similarity is considered in the context

SUBMITTER: Wiedemann J 

PROVIDER: S-EPMC5651598 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature