IL-17 signalling restructures the nasal microbiome and drives dynamic changes following Streptococcus pneumoniae colonization.

ABSTRACT:

Background

The bacterial pathogen Streptococcus pneumoniae colonizes the nasopharynx prior to causing disease, necessitating successful competition with the resident microflora. Cytokines of the IL-17 family are important in host defence against this pathogen but their effect on the nasopharyngeal microbiome is unknown. Here we analyse the influence of IL-17 on the composition and interactions of the nasopharyngeal microbiome before and after pneumococcal colonization.

Results

Using a murine model and 16S rRNA profiling, we found that a lack of IL-17 signalling led to profound alterations in the nasal but not lung microbiome characterized by decreased diversity and richness, increases in Proteobacteria and reduction in Bacteroidetes, Actinobacteria and Acidobacteria. Followi

SUBMITTER: Ritchie ND 

PROVIDER: S-EPMC5651609 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature