Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids.

ABSTRACT: Mycobacterium tuberculosis is a major human pathogen that is able to survive inside host cells and resist immune clearance. Most particularly, it inhibits several arms of the innate immune response, including phagosome maturation or cytokine production. To better understand the molecular mechanisms by which M. tuberculosis circumvents host immune defenses, we used a transposon mutant library generated in a virulent clinical isolate of M. tuberculosis of the W/Beijing family to infect human macrophages, utilizing a cell line derivative of THP-1 cells expressing a reporter system for activation of the transcription factor NF-κB, a key regulator of innate immunity. We identified several M. tuberculosis mutants inducing a NF-κB activation stronger than that of the w

SUBMITTER: Blanc L 

PROVIDER: S-EPMC5651758 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature