Helicobacter pylori γ-glutamyl transferase contributes to colonization and differential recruitment of T cells during persistence.

ABSTRACT: Helicobacter pylori γ-glutamyl transferase (gGT) is a key bacterial virulence factor that is not only important for bacterial gastric colonization but also related to the development of gastric pathology. Despite accumulating evidence for pathogenic and immunologic functions of H. pylori gGT, it is still unclear how it supports gastric colonization and how its specific effects on the host's innate and adaptive immune responses contribute to colonization and pathology. We have compared mice showing similar bacterial load after infection with gGT-proficient or gGT-deficient H. pylori to analyse the specific role of the enzyme during infection. Our data indicate that H. pylori gGT supports initial colonization. Nevertheless, bacteria lacking gGT can still colonize and persist. We observed tha

SUBMITTER: Wustner S 

PROVIDER: S-EPMC5651840 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature