A New Generation of Arachidonic Acid Analogues as Potential Neurological Agent Targeting Cytosolic Phospholipase A₂.

ABSTRACT: Cytosolic phospholipase A₂ (cPLA₂) is an enzyme that releases arachidonic acid (AA) for the synthesis of eicosanoids and lysophospholipids which play critical roles in the initiation and modulation of oxidative stress and neuroinflammation. In the central nervous system, cPLA₂ activation is implicated in the pathogenesis of various neurodegenerative diseases that involves neuroinflammation, thus making it an important pharmacological target. In this paper, a new class of arachidonic acid (AA) analogues was synthesized and evaluated for their ability to inhibit cPLA₂. Several compounds were found to inhibit cPLA₂ more strongly than arachidonyl trifluoromethyl ketone (AACOCF₃), an inhibitor that is commonly used in the study o

SUBMITTER: Ng CY 

PROVIDER: S-EPMC5651845 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature