Ultrasound localization microscopy to image and assess microvasculature in a rat kidney.

ABSTRACT: The recent development of ultrasound localization microscopy, where individual microbubbles (contrast agents) are detected and tracked within the vasculature, provides new opportunities for imaging the vasculature of entire organs with a spatial resolution below the diffraction limit. In stationary tissue, recent studies have demonstrated a theoretical resolution on the order of microns. In this work, single microbubbles were localized in vivo in a rat kidney using a dedicated high frame rate imaging sequence. Organ motion was tracked by assuming rigid motion (translation and rotation) and appropriate correction was applied. In contrast to previous work, coherence-based non-linear phase inversion processing was used to reject tissue echoes while maintaining echoes from very slowly moving m

SUBMITTER: Foiret J 

PROVIDER: S-EPMC5651923 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature