Low CLL-1 Expression Is a Novel Adverse Predictor in 123 Patients with De Novo CD34⁺ Acute Myeloid Leukemia.

ABSTRACT: Recent reports state that C-type lectin-like molecule-1 (CLL-1) in acute myeloid leukemia (AML) is expressed primarily on myeloid cells, but there is still no investigation about its prognostic significance on leukemic blast compartment. Hence, this study aimed to evaluate the prognostic value of CLL-1 in 123 patients with de novo CD34⁺ Non-M3 AML. Multiparameter flow cytometry was used to assess the expression of CLL-1 on immature compartment in AML and control groups. We found that CLL-1 expression level on blast compartment was closely linked to clinical characteristics, treatment response, and survival outcome of patients. Decreased expression of CLL-1 was observed on immature compartment from AML patients as compared with controls (62.6% vs. 86.5%, P < 0.05). Logistic model

SUBMITTER: Wang YY 

PROVIDER: S-EPMC5651960 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature