Classification and survival prediction for early-stage lung adenocarcinoma and squamous cell carcinoma patients.

ABSTRACT: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-associated mortality worldwide. Adenocarcinoma (AC) and squamous cell carcinoma (SCC) are two primary histological subtypes of NSCLC, accounting for ~70% of lung cancer cases. Increasing evidence suggests that AC and SCC differ in the composition of genes and molecular characteristics. Previous research has focused on distinguishing AC from SCC or predicting the NSCLC patient survival rates using gene expression profiles, usually with the aid of a feature selection method. The present study conducted a pre-filtering to identify the genes that have significant expression values and a high connection with other genes in the gene network, and then used the radial coordinate visualization method to identify relevant genes. By appl

SUBMITTER: Tian S 

PROVIDER: S-EPMC5652232 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature