Human Kidney Tubule-Specific Gene Expression Based Dissection of Chronic Kidney Disease Traits.

ABSTRACT: Chronic kidney disease (CKD) has diverse phenotypic manifestations including structural (such as fibrosis) and functional (such as glomerular filtration rate and albuminuria) alterations. Gene expression profiling has recently gained popularity as an important new tool for precision medicine approaches. Here we used unbiased and directed approaches to understand how gene expression captures different CKD manifestations in patients with diabetic and hypertensive CKD. Transcriptome data from ninety-five microdissected human kidney samples with a range of demographics, functional and structural changes were used for the primary analysis. Data obtained from 41 samples were available for validation. Using the unbiased Weighted Gene Co-Expression Network Analysis (WGCNA) we identified 16 co-expr

SUBMITTER: Beckerman P 

PROVIDER: S-EPMC5652292 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature