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High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium.

ABSTRACT: Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 ?g/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays.

SUBMITTER: Guo Y 

PROVIDER: S-EPMC5652432 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium.

Guo Yan Y   Tomich Adam D AD   McElheny Christi L CL   Cooper Vaughn S VS   Tait-Kamradt Amelia A   Wang Minggui M   Hu Fupin F   Rice Louis B LB   Sluis-Cremer Nicolas N   Doi Yohei Y  

Emerging infectious diseases 20171101 11

Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays. ...[more]

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