High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium.

ABSTRACT: Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays.

SUBMITTER: Guo Y 

PROVIDER: S-EPMC5652432 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature