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Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing.

ABSTRACT: After conventional molecular and serologic testing failed to diagnose the cause of illness, deep sequencing identified spotted fever group Rickettsia DNA in a patient's blood sample. Sequences belonged to R. honei, the causative agent of Flinders Island spotted fever. Next-generation sequencing is proving to be a useful tool for clinical diagnostics.

SUBMITTER: Graham RMA

PROVIDER: S-EPMC5652451 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing.

Graham Rikki M A RMA Donohue Steven S McMahon Jamie J Jennison Amy V AV

Emerging infectious diseases 20171101 11

After conventional molecular and serologic testing failed to diagnose the cause of illness, deep sequencing identified spotted fever group Rickettsia DNA in a patient's blood sample. Sequences belonged to R. honei, the causative agent of Flinders Island spotted fever. Next-generation sequencing is proving to be a useful tool for clinical diagnostics. ...[more]

PMID: 29048295

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