Diurnal cortisol and mental well-being in middle and older age: evidence from four cohort studies.

ABSTRACT:

Objectives

We conducted an individual participant meta-analysis to test the hypothesis that cortisol patterns indicative of dysregulated hypothalamic-pituitary-adrenal axis functioning would be prospectively associated with poorer well-being at follow-up.

Setting

Four large UK-based cohort studies.

Participants

Those providing valid salivary or serum cortisol samples (n=7515 for morning cortisol; n=1612 for cortisol awakening response) at baseline (age 44-82) and well-being data on the Warwick Edinburgh Mental Wellbeing Scale at follow-up (0-8 years) were included.

Results

Well-being was not associated with morning cortisol, diurnal slope or awakening response though a borderline association with evening cortisol was found. Adjusting for sex and follow-up time,

SUBMITTER: Stafford M 

PROVIDER: S-EPMC5652457 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature