Drugs and life-threatening ventricular arrhythmia risk: results from the DARE study cohort.

ABSTRACT:

Objectives

To establish a unique sample of proarrhythmia cases, determine the characteristics of cases and estimate the contribution of individual drugs to the incidence of proarrhythmia within these cases.

Setting

Suspected proarrhythmia cases were referred by cardiologists across England between 2003 and 2011. Information on demography, symptoms, prior medical and drug histories and data from hospital notes were collected.

Participants

Two expert cardiologists reviewed data for 293 referred cases: 130 were included. Inclusion criteria were new onset or exacerbation of pre-existing ventricular arrhythmias, QTc >500 ms, QTc >450 ms (men) or >470 ms (women) with cardiac syncope, all secondary to drug administration. Exclusion criteria were acute ischaemia and ischaemic

SUBMITTER: Coughtrie AL 

PROVIDER: S-EPMC5652462 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature